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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Recombination hotspot ： ウィキペディア英語版 Recombination hotspot Recombination hotspots are regions in a genome that exhibit elevated rates of recombination relative to a neutral expectation. The peak recombination rate within hotspots can be hundreds or thousands of times that of the surrounding region. Recombination hotspots can occur through meiotic recombination during crossing over events or through errors in DNA replication that lead to genomic rearrangements. ==Meiotic Recombination== Meiotic recombination through crossing over is thought to be the mechanism by which a cell ensures correct segregation of homologous chromosomes. Crossing over requires a DNA double-stranded break followed by strand invasion of the homolog and subsequent repair.〔Baudat, F., et al. "Prdm9 Is a Major Determinant of Meiotic Recombination Hotspots in Humans and Mice." Science 327.5967 (2010): 836-40. Print.〕 Initiation sites for recombination are usually identified by mapping crossing over events through pedigree analysis or through analysis of linkage disequilibrium. Linkage disequilibrium has identified more than 30,000 hotspots within the human genome.〔 In humans, the average number of crossover recombination events per hotspot is one crossover per 1,300 meioses, and the most extreme hotspot has a crossover frequency of one per 110 meioses. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Recombination hotspot」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.